ABSTRACT
Serum alpha 1-antitrypsin, alpha 1-antichymotrypsin and alpha 2-macroglobulin increased significantly in patients suffering from liver diseases: hepatoma, amoebic liver abscess, hepatitis, hepatic cirrhosis, cholangiocarcinoma, carcinoma of the head of pancreas including liver fluke infection (opisthorchiasis). Marked increase of alpha 1-antitrypsin and alpha 1-antichymotrypsin were found in cholangiocarcinoma, carcinoma of the head of pancreas, amoebic liver abscess, hepatic cirrhosis and hepatoma. alpha 2-macroglobulin increased markedly in hepatic cirrhosis. The concentrations of protease inhibitors found in opisthorchiasis were only moderately elevated.
Subject(s)
Adenoma, Bile Duct/blood , Adult , Bile Duct Neoplasms/blood , Carcinoma, Hepatocellular/blood , Female , Humans , Liver Diseases/blood , Liver Neoplasms/blood , Male , Middle Aged , Opisthorchiasis/blood , Protease Inhibitors/blood , alpha 1-Antichymotrypsin/analysis , alpha 1-Antitrypsin/analysis , alpha-Macroglobulins/analysisABSTRACT
The infrared spectrum of native black-eyed pea trypsin and chymotrypsin inhibitor (BTCI) in solid film was measured from 550 to 1750 cm-1 and amide I-III, and V regions have been analyzed. By comparison between the observed bands with the modes calculated for several structures (available inthe literature), the occurrence in BTCI of unordered, antipatallel ß-sheet, and ß-turn structures is suggested